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Low retention tips, often referred to as low binding tips, are modified pipette tips that have been created with the goal of preventing fluid substances like enzymes, DNA, cells, and proteins from adhering to their surface. You might observe that only trace amounts of liquid are left over after dispensing if you look at a regular pipet tip. Low-retention tips prevent this from happening by preventing the liquid from adhering to the inside of the tips because they include a hydrophobic plastic component. They are made from a substance called polypropylene, and to lessen sample binding and adhesion to the plastic surface, the surface has either been chemically or physically changed.
